Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis
| Autor: | Andrew C. Karaplis, Gloria Assaker, Siham Sabri, Rui Zhang, Jiarong Li, Richard Kremer, Anne Camirand |
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| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
Parathyroid hormone-related protein business.industry Cancer medicine.disease Metastasis 03 medical and health sciences Paracrine signalling 0302 clinical medicine Breast cancer Tumor progression Cancer research Medicine 030212 general & internal medicine business Autocrine signalling hormones hormone substitutes and hormone antagonists Brain metastasis |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783030222536 |
| DOI: | 10.1007/978-3-030-22254-3_13 |
| Popis: | PTHrP was first discovered as the most common mediator of malignancy-associated hypercalcemia. Subsequently, the discovery of its ubiquitous expression in normal tissues unraveled its role as a physiological autocrine/paracrine regulator. The significance of PTHrP in cancer is not confined to malignancy-associated hypercalcemia, and sufficient evidence now also supports its role in skeletal metastasis through its modulation of bone turnover. Furthermore, our own studies have recently shown the critical role of PTHrP in breast cancer initiation, growth, and metastasis. More recently, we have provided new evidence that overexpression of PTHrP is associated with higher incidence of brain metastasis and decreased overall survival in triple-negative breast cancer patients. Further mechanistic studies in human and mouse model are necessary to fully understand the role of PTHrP in tumor progression and metastasis. |
| Databáze: | OpenAIRE |
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