IgM regulates airway hyperresponsiveness in allergic asthma through acetyl choline receptors

Autor:	Sabelo Hadebe, Jermaine Khumalo, Amkele Ngomti, Sandisiwe Mangali, Martyna Scibiorek, Frank Brombacher
Rok vydání:	2020
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 204:65.23-65.23
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.204.supp.65.23
Popis:	Allergic asthma is a disease driven by T helper 2 (TH2)-type cells secreting interleukin (IL-) 4, 5 and 13. It is characterized by eosinophils, airway hyperesponsiveness (AHR) and IgE secreting B cells. B cells play a role in allergic asthma in an allergen load dependent manner. IgM isotype secreted by naïve B cells is important for class switching. It is currently unclear how IgM isotype contributes in the development of allergic asthma. We investigated the role of IgM isotype in a house dust mite (HDM)-induced TH2 allergic asthma model. We sensitised wild type (wt), IgM-deficient (IgM−/−) and B cell-deficient (uMT−/−) mice with high (>10 ug) and low (
Databáze:	OpenAIRE
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