A novel method for the synthesis of pyrido[1,2-b][2]benzazepines on the basis of 2-(bromomethyl)benzophenones and 2-(bromomethyl)benzaldehyde

Autor:	L. M. Potikha, V. A. Kovtunenko, V. V. Sypchenko
Rok vydání:	2020
Předmět:	Benzazepines 010405 organic chemistry Organic Chemistry Nuclear magnetic resonance spectroscopy 010402 general chemistry Mass spectrometry 01 natural sciences Medicinal chemistry 0104 chemical sciences Benzazepine Benzaldehyde chemistry.chemical_compound chemistry Moiety Heating time
Zdroj:	Chemistry of Heterocyclic Compounds. 56:1454-1459
ISSN:	1573-8353 0009-3122
Popis:	A novel method for the synthesis of pyrido[1,2-b][2]benzazepine derivatives is based on the reaction of 2-(bromomethyl)benzophenones and 2-(bromomethyl)benzaldehyde with 2-methylpyridines. The route of synthesis of 6H-pyrido[1,2-b][2]benzazepinium salts includes several steps with the possibility of isolating intermediate 1-benzyl-2-methylpyridinium and 11-aryl-11-hydroxy-11,12-dihydro-6Hpyrido[1,2-b][2]benzazepinium bromides. The efficiency of dehydration of intermediate carbinols increases with the use of protic solvents, an increase in heating time, and in the presence of electron-withdrawing substituents in the benzazepine moiety. The structure of the reaction products was proved by mass spectrometry, IR and one- and two-dimensional correlation NMR spectroscopy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0713daa09b4a9a209cbfe61c60de8aa4 https://doi.org/10.1007/s10593-020-02837-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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