| Autor: |
Madeleine EB Butler, Melissa J Jansen van Rensburg, Angela Karani, Benedict Mvera, Donald Akech, Asma Akter, Calum Forrest, Andries J van Tonder, Sigríður J Quirk, Gunnsteinn Haraldsson, Stephen D Bentley, Helga Erlendsdóttir, Ásgeir Haraldsson, Karl G Kristinsson, J Anthony G Scott, Angela B Brueggemann |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.11.03.514821 |
| Popis: |
Bacteriocins are antimicrobial peptides produced by bacteria to inhibit other bacteria in the surrounding environment.Streptococcus pneumoniaeis a leading cause of disease worldwide and colonises the healthy human nasopharynx, where it competes for space and nutrients. Pneumococcal conjugate vaccines have reduced the incidence of disease, but they also restructure the bacterial population, and this restructuring likely alters the nasopharyngeal competition dynamics. Here, the distribution of bacteriocins was examined in over 5000 carriage and disease-causing pneumococci from Iceland and Kenya, recovered before and after the introduction of pneumococcal vaccination. Overall, up to eleven different bacteriocin gene clusters were identified per pneumococcus. Significant differences in the prevalence of bacteriocins were observed before and after vaccine introduction, and among carriage and disease-causing pneumococci, which were largely explained by the bacterial population structure. Genetically similar pneumococci generally harboured the same bacteriocins although sometimes different repertoires of bacteriocins were observed, which suggested that horizontal transfer of bacteriocin clusters had occurred. These findings demonstrated that vaccine-mediated changes in the pneumococcal population altered the prevalence and distribution of bacteriocins. The consequences of this for pneumococcal colonisation and disease remain to be determined. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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