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This study was carried out to determine the curative effect of aqueous stem bark extract of Erythrina mildbraedii in rats induced with nephrotoxicity using 800mg/kg Acetaminophen. Acetaminophen administration resulted in significant increase in the serum level of urea, creatinine, Na + , K + , Cl - and a significant decrease in the level of HCO 3 - . Administration of different doses (50, 100, & 150mg/kg) of aqueous stem bark extract of Erythrina mildbraedii ameliorated the effect of Acetaminophen indicated by a significant decrease in the level of urea, creatinine, Na + , K + , Cl - and an increase in the level of HCO 3 - when compared to control rats. The histopathology showed a restoration of the renal architectures after administration of the aqueous stem bark extract. Keywords : Acetaminophen, Erythrina mildbraedii, nephrotoxicity, aqueous extract. |
