Levels of serum antibodies to enterobacterial lipopolysaccharides and
| Autor: | Gordienko Ai |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology C-reactive protein Case-control study Inflammation Normal values biology.organism_classification medicine.disease Biochemistry Enterobacteriaceae Immune system Endocrinology Internal medicine Diabetes mellitus Immunology biology.protein medicine lipids (amino acids peptides and proteins) Antibody medicine.symptom |
| Zdroj: | The Ukrainian Biochemical Journal. 87:98-106 |
| ISSN: | 2409-4943 |
| DOI: | 10.15407/ubj87.03.098 |
| Popis: | We examined patients with type 1 (DM 1) and type 2 (DM 2) diabetes mellitus. The concentration of C-reactive protein (CRP) in the blood and levels of serum antibodies to different classes of enterobacterial lipopolysaccharides (LPS) were determined by ELISA. Using cluster analysis it was shown that in 40.8% DM-1 patients the increased concentration of CRP is associated with a decrease in the levels of serum anti-LPS-IgA, anti-LPS-IgM and anti-LPS-IgG. In 56.7% of DM-2 patients with increased concentration of CRP levels of serum anti-LPS-IgA and anti-LPS-IgM were not significantly different from the normal values, but the levels of serum anti-LPS-IgG were significantly increased. Activation of inflammation and increase of concentration of the CRP in the blood of DM-2 patients is accompanied by a significant increase in the levels of serum anti-LPS-A and anti-LPS-G, as well as the tendency to reduce the levels of anti-LPS-IgM. The results of this study suggest an association between low intensity inflammation and immune response to enterobacterial LPS in type 1 and 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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