| Autor: | Henderik W. Frijlink, Roelof Oosting, Nanco R. Hefting, Dirk K. F. Meijer, Coenraad F. Lerk, Jan Visser |
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| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Cyclodextrin Organic Chemistry Inulin technology industry and agriculture Pharmaceutical Science Beta-Cyclodextrins Intestinal absorption Nephrotoxicity Phenolphthalein carbohydrates (lipids) chemistry.chemical_compound Pharmacokinetics chemistry Oral administration polycyclic compounds Molecular Medicine lipids (amino acids peptides and proteins) Pharmacology (medical) Biotechnology |
| Zdroj: | Pharmaceutical Research. :1248-1252 |
| ISSN: | 0724-8741 |
| Popis: | Hydroxypropyl-beta-cyclodextrin was analyzed by HPLC using postcolumn complexation with phenolphthalein and negative colorimetric detection, with a detection limit of 20 micrograms/ml. The pharmacokinetics of beta-cyclodextrin and of hydroxypropyl-beta-cyclodextrin were studied after intravenous administration to permanently cannulated rats. The pharmacokinetic behavior of both cyclodextrins was similar to that of inulin, showing rapid distribution over extracellular fluids. Elimination occurred through glomerular filtration. When a dose of 200 mg/kg beta-cyclodextrin was administered the elimination rate was decreased, probably as a result of nephrotoxicity of beta-cyclodextrin. Within 24 hr after administration most of the cyclodextrin dose was recovered unchanged in urine. After oral administration, only insignificant amounts of intact beta-cyclodextrin were absorbed from the gastrointestinal tract. |
| Databáze: | OpenAIRE |
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