Structural Assignment of the Peptide Antibiotic LP237-F8, a Metabolite of Tolypocladium geodes

Autor:	Youla S. Tsantrizos, Sotiria Pischos, Françoise Sauriol
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Stereochemistry medicine.drug_class Metabolite Organic Chemistry Antibiotics Peptaibol Peptide Carbon-13 NMR Amino acid chemistry.chemical_compound chemistry Tolypocladium geodes medicine Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	The Journal of Organic Chemistry. 61:2118-2121
ISSN:	1520-6904 0022-3263
Popis:	Antibiotic LP237-F8 is the main cytotoxic metabolite isolated from the liquid cultures of the fungus Tolypocladium geodes. Complete 1H and 13C NMR resonance assignments and sequencing of the peptide was achieved by extensive high-field 2D NMR spectroscopy. The N- and C-terminals of LP237-F8 are protected with a capryloyl unit and the amino alcohol leucinol, respectively. This linear peptide is a new member of the peptaibol class of natural products, containing the unusual amino acids α-aminoisobutyric acid (Aib) and α-amino-α-ethyl-n-pentanoic acid (α-ethylnorvaline, α-EtNor).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::070856911602575ad98f0893a1d6b067 https://doi.org/10.1021/jo951837t Zobrazit plný text záznamu