Green synthesis of symmetrical N, N′-disubstituted thiourea derivatives in water using solar energy

Autor:	Asha D. Jangale, Jyotsna S. Meshram, Priyanka P. Kumavat, Kiran S. Dalal, Dipak S. Dalal, Dipak R. Patil
Rok vydání:	2013
Předmět:	Thiophosgene Primary (chemistry) business.industry Solar thermal energy Antimicrobial Solar energy Catalysis chemistry.chemical_compound chemistry Thiourea Environmental Chemistry Organic chemistry Amine gas treating business
Zdroj:	Environmental Chemistry Letters. 11:177-182
ISSN:	1610-3661 1610-3653
DOI:	10.1007/s10311-012-0394-y
Popis:	Thioureas are of importance in medicinal chemistry due to their biological activities such as antituberculosis, anti-HIV, analgesic, anti-inflammatory, antimicrobial, antiarrhythmic, fungicide, herbicides, rodenticides and as phenoloxidase enzymatic inhibitors. Treatment of primary and secondary amines with thiophosgene is the common method of making symmetrical disubstituted thioureas. However, this method is hazardous due to the toxic properties of thiophosgene. Here, we report a green, operationally simple approach for the synthesis of 1, 3-disubstituted thiourea derivatives in moderate to excellent yields of 57–99 %. We use primary amines and CS2 in water without any catalyst and solar thermal energy. This method is more environmentally benign and energy-saving compared with previously reported methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06ff9a8afdaaced3f536b1be6e304c61 https://doi.org/10.1007/s10311-012-0394-y Zobrazit plný text záznamu Full text from SpringerLink