Effects of Nutritional Supplement with α-Lipoic Acid in Patients with Recurrent Pterygium
| Autor: | Francisco Javier Galvez Gastelum, Irinea Yañez Sanchez, Leonel García Benavides, Jorge Guillermo Hurtado Godinez, ez Cañaveral, Sara Pascoe Gonzalez, Ivan Isidro Hern |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant business.industry Angiogenesis medicine.medical_treatment medicine.disease_cause medicine.disease Placebo eye diseases Pterygium Extracellular matrix Lipoic acid chemistry.chemical_compound chemistry medicine Immunohistochemistry lipids (amino acids peptides and proteins) sense organs business Oxidative stress |
| Zdroj: | Journal of Clinical & Experimental Ophthalmology. |
| ISSN: | 2155-9570 |
| DOI: | 10.4172/2155-9570.1000338 |
| Popis: | Background: Pterygium is an ocular disease characterized by fibro-proliferative disarray of the corneal surface. Control of oxidative stress with effective antioxidant supplementation, like α-lipoic acid, could prevent recurrence following surgical resection.Materials and methods: This study was a randomized placebo-controlled, double-blind trial. Seventy patients with recurrent pterygium participated. Oral therapy with α-lipoic acid or placebo was administered. Pterygium tissue was collected for histological and immunohistochemical analysis.Results: Pterygium recurrence was similar in both groups. A significant increment of fibroelastic tissue was observed in the placebo compared with the α-lipoic acid group. Number and caliber of blood vessels, extracellular matrix content and presence of inflammatory infiltrated cells decreased in the α-lipoic acid group. Myofibroblasts were also localized and smaller.Conclusions: Treatment with α-lipoic acid improved clinical appearances through decreased fibroelastic tissue size. Recurrence was similar. Blood vessels, extracellular matrix content and inflammatory infiltrated cells reduced with α-lipoic acid. |
| Databáze: | OpenAIRE |
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