Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patientsThis article is one of a selection of papers published in the special issue Bridging the Gap: Where Progress in Cardiovascular and Neurophysiologic Research Meet
| Autor: | S. Stankovic, Zorica Rasic-Milutinovic, M. Ilic, Steva Pljesa, R. Maletic, Gordana Perunicic-Pekovic |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
medicine.medical_specialty Creatinine Ejection fraction Physiology Cholesterol business.industry medicine.medical_treatment Inflammation General Medicine medicine.disease Gastroenterology Proinflammatory cytokine chemistry.chemical_compound Malnutrition Endocrinology chemistry Physiology (medical) Internal medicine medicine Population study Hemodialysis medicine.symptom business |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 86:205-209 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in patients on hemodialysis. The study population consisted of 42 hemodialysis patients with different parameters of malnutrition. Blood samples were taken after an overnight fast, and plasma lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured by using conventional enzymatic methods. Serum urea and creatinine levels were also measured by routine procedures. Plasma high-sensitivity C-reactive protein level (hs-CRP), TNF-α, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Standard Doppler echo examinations were used to determine plaque on carotid arteries, and end-diastolic diameter (EDD) and ejection fraction (EF) were measured by echocardiography. Malnourished patients exhibited significantly greater evidence of cardiovascular disease and carotid plaques. Factor (principal component) analysis indicated 6 latent factors with 67.5% of the variance explained within all investigated parameters. Cluster analysis was used to distinguish the inflammatory markers and the nutritional markers from other parameters and to visualize similarities between variables. In summary, this cross-sectional study in hemodialysis patients found a high prevalence of malnutrition, inflammation, carotid plaques, and cardiovascular disease. Malnourished dialysis patients are more often found with cardiovascular disease and carotid plaques. In addition, these patients have higher levels of inflammatory cytokines, which may partly explain the elevated risk for atherosclerotic vascular disease. |
| Databáze: | OpenAIRE |
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