Investigations into Concurrent Exposure to Green Tea Extract and Phenytoin on the Incidence of Cleft Palate in CD-1 Mice

Autor:	Xuan T. Lam, Amanda L. Logsdon, Hanna Kim, Kyle K. Wells, Dokyong Kim, Brittany M. Miller, Ronald D. Hood, Jarrett E. Lockard, Melissa M. Bailey, Betty J. Herring
Rok vydání:	2015
Předmět:	Phenytoin chemistry.chemical_classification Reactive oxygen species business.industry Fetal hydantoin syndrome Green tea extract Pharmacology medicine.disease Toxicology Phenytoin Sodium Anticonvulsant Agent chemistry Medicine Gestation business Adverse effect medicine.drug
Zdroj:	Transactions of the Kansas Academy of Science. 118:97-104
ISSN:	1938-5420 0022-8443
DOI:	10.1660/062.118.0111
Popis:	Phenytoin (PHT) is an efficacious anticonvulsant agent that is commonly used in the treatment of epileptic seizures. However, the use of phenytoin during pregnancy is associated with a group of birth defects known as Fetal Hydantoin Syndrome (FHS), which include cleft palate and retarded growth. Phenytoin may cause its adverse effects through the production of reactive oxygen species (ROS). Green tea extract (GTE) contains epigallocatechin-3-gallate (EGCG), which exhibits free radical scavenging activity and may attenuate the effects of ROS. The purpose of this study was to investigate the potential of administration of GTE to attenuate teratogenic effects induced by phenytoin. Phenytoin sodium salt (in DI water adjusted to pH 11) was administered via gavage on gestation days (GD) 12 and 13, and its controls were dosed with pH-adjusted water on GD 12 and 13. GTE or DI water was administered from GD 8–16 to mated CD-1 mice. Controls received both vehicles (DI water and pH-adjusted water). Mated females wer...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06e874808708a4dd1f08ac29097c0ff2 https://doi.org/10.1660/062.118.0111 Zobrazit plný text záznamu