MP65-04 A NOVEL REGENERATIVE TREATMENT FOR FEMALE STRESS URINARY INCONTINENCE: LONG-TERM OUTCOME OF INITIAL THREE CASES UNDERGOING PERIURETHRAL INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED REGENERATIVE CELLS
Autor: | Yasuhito Funahashi, Yoshihisa Matsukawa, Tokunori Yamamoto, Momokazu Gotoh |
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Rok vydání: | 2016 |
Předmět: | |
Zdroj: | Journal of Urology. 195 |
ISSN: | 1527-3792 0022-5347 |
Popis: | METHODS: ISD was created in female NHPs by cutting and then cauterizing the pudendal innervation to the urinary sphincter complex. Chronic fibrotic, muscle poor ISD developed within 6 months post-surgery. Partial bone marrow transplantation with autologous Lenti-GFP bone marrow cells (BMCs) was performed and NHPs (n1⁄46/ experimental condition) were then given sphincter injections of LentiMcherry-labeled 5 million autologous skMPCs, or SDF-1a. Tissues were removed 6 months later and analyzed for sphincter content of muscle, collagen, BMCs, skMPCs and SDF-1a. RESULTS: When compared to previously studied NHPs with acute ISD (Badra et al, J Urol. 2013;190(5):1938), there was less expression of BMCs andSDF-1a in the urinary sphincter complexes ofNHPswith chronic ISD (p |
Databáze: | OpenAIRE |
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