MP65-04 A NOVEL REGENERATIVE TREATMENT FOR FEMALE STRESS URINARY INCONTINENCE: LONG-TERM OUTCOME OF INITIAL THREE CASES UNDERGOING PERIURETHRAL INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED REGENERATIVE CELLS

Autor:	Yasuhito Funahashi, Yoshihisa Matsukawa, Tokunori Yamamoto, Momokazu Gotoh
Rok vydání:	2016
Předmět:	medicine.medical_specialty business.industry Urology Urethral sphincter Adipose-Derived Regenerative Cells Urinary incontinence Structure and function medicine.anatomical_structure medicine Sphincter Bone marrow medicine.symptom business Sphincter muscle Homing (hematopoietic)
Zdroj:	Journal of Urology. 195
ISSN:	1527-3792 0022-5347
Popis:	METHODS: ISD was created in female NHPs by cutting and then cauterizing the pudendal innervation to the urinary sphincter complex. Chronic fibrotic, muscle poor ISD developed within 6 months post-surgery. Partial bone marrow transplantation with autologous Lenti-GFP bone marrow cells (BMCs) was performed and NHPs (n1⁄46/ experimental condition) were then given sphincter injections of LentiMcherry-labeled 5 million autologous skMPCs, or SDF-1a. Tissues were removed 6 months later and analyzed for sphincter content of muscle, collagen, BMCs, skMPCs and SDF-1a. RESULTS: When compared to previously studied NHPs with acute ISD (Badra et al, J Urol. 2013;190(5):1938), there was less expression of BMCs andSDF-1a in the urinary sphincter complexes ofNHPswith chronic ISD (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06df377ef79f064e935287a89b4060dd https://doi.org/10.1016/j.juro.2016.02.1215 Zobrazit plný text záznamu