Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq

Autor: null Banan Kareem Bedewi, null Ghaith Ali Jasim, null Ibrahim Saleh Abbas, null BasmaTalib Al-Sudani
Rok vydání: 2022
Předmět:
Zdroj: Al Mustansiriyah Journal of Pharmaceutical Sciences. 22:35-43
ISSN: 1815-0993
DOI: 10.32947/ajps.v22i2.837
Popis: oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities. Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.
Databáze: OpenAIRE