Organolithium mediated synthesis of prenylchalcones as potential inhibitors of chemoresistance

Autor:	Denis Barron, François Thomasson, Attilio Di Pietro, Gilles Comte, Jean Baptiste Daskiewicz
Rok vydání:	1999
Předmět:	Chalcone chemistry.chemical_compound Prenylation Aldol reaction Chemistry Stereochemistry Organic Chemistry Drug Discovery Cancer cell Aldol condensation Biochemistry
Zdroj:	Tetrahedron Letters. 40:7095-7098
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)01461-6
Popis:	A number of substituted chalcones have been prepared by a novel LiHMDS-mediated aldol condensation, the first method consistent with the use of alkali-labile protecting groups such as tert-butyldiphenylsilyl or tert-butyldimethylsilyl. Chalcone substitution by prenylation increases their binding affinity to P-glycoprotein responsible for cancer cells chemoresistance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06d880f18eb454e7744ac52b91f7d4d0 https://doi.org/10.1016/s0040-4039(99)01461-6 Zobrazit plný text záznamu Full Text from ScienceDirect