The renin-angiotensin-aldosterone system and Covid-19. From basis to therapeutics

Autor:	Bernard I. Levy
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Coronavirus disease 2019 (COVID-19) biology business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Cardiovascular homeostasis Hematology Disease Pharmacology Enzyme assay Enzyme chemistry Renin–angiotensin system biology.protein Medicine Angiotensin Receptor Blockers business
Zdroj:	Sang thrombose vaisseaux. 32:260-268
ISSN:	1950-6104 0999-7385
Popis:	Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavi-rus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells In this review, we summarized the biology of this enzyme which plays a key role in cardiovascular homeostasis and blood pressure control Blockers of the renin-angiotensin-aldosterone system modify the expression and activity of angiotensin-converting enzyme 2, possibly in different ways The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed © 2020, John Libbey All rights reserved
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06d327c88d2b8753f6265197224449cb https://doi.org/10.1684/stv.2020.1143 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.