A case report on the management of severe vasospasm in subarachnoid hemorrhagic patients using intra-arterial nimodipine, intrathecal sodium nitroprusside and intra-arterial papaverine
| Autor: | Sajesh K Menon, Jiya Marium George, Athul Gopan, Anila Kn, Sreehari Nr, Sheen Reynold |
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| Rok vydání: | 2020 |
| Předmět: |
Papaverine
Side effect business.industry Cerebral arteries Vasospasm medicine.disease nervous system diseases Cerebral vasospasm medicine.anatomical_structure Anesthesia cardiovascular system medicine cardiovascular diseases Sodium nitroprusside General Pharmacology Toxicology and Pharmaceutics Subarachnoid space business Nimodipine medicine.drug |
| Zdroj: | International Journal of Research in Pharmaceutical Sciences. 11:7334-7337 |
| ISSN: | 0975-7538 |
| DOI: | 10.26452/ijrps.v11i4.3876 |
| Popis: | Management and prevention of vasospasm in subarachnoid haemorrhage are one of the complex dictums so far. Aneurysmal subarachnoid haemorrhage (aSAH) is the condition in which bleeding occurs in subarachnoid space. Vasospasm is a complex immunologically active phenomenon which requires a multimodality approach in the treatment of established vasospasm. Various treatment strategies for vasospasm and related disabilities include vasodilators such as nimodipine, sodium nitroprusside and papaverine. Intra-arterial nimodipine shows drastic improvement in several patients by resolving and preventing vasospasm. Intra-arterial administration of nimodipine can cause hypotension which can be easily managed. Papaverine is also an efficient drug-producing vasodilatory action on cerebral arteries. Papaverine is considered as the first intraarterial agent to reduce angiographic cerebral vasospasm which has the side effect of elevated intracranial pressure. Besides, the intrathecal administration of sodium nitroprusside has also demonstrated the effect in ischemic vasospasm after subarachnoid haemorrhage. Intraarterial administration of this drug can induce arterial hypotension which is not a recommended method. Vomiting is the main side effect of sodium nitroprusside, which can be managed with antiemetics such as ondansetron. Here we present a case of management of cerebral vasospasm in subarachnoid patients using the combination of these three effective drugs which showed a remarkable improvement in the resolution of aneurysmal vasospasm. |
| Databáze: | OpenAIRE |
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