The design analysis of continuous bioreactors in series with recirculation using Singular Value Decomposition
| Autor: | C.A. Gómez-Pérez, Jairo Espinosa |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine Mathematical optimization Series (mathematics) General Chemical Engineering Process (computing) General Chemistry System of linear equations 01 natural sciences 03 medical and health sciences 030104 developmental biology 010608 biotechnology Linear algebra Singular value decomposition Bioreactor Production (economics) Representation (mathematics) Mathematics |
| Zdroj: | Chemical Engineering Research and Design. 125:108-118 |
| ISSN: | 0263-8762 |
| Popis: | Continuous bioreactors in series with recirculation can approximately be modeled by using a system of linear equations of the form Ax = 0. Using such representation, Singular Value Decomposition (SVD) is used as analysis tool and some interesting features appear. This method is introduced as an attractive option to apply the theory of continuous bioreactors to industrial scale. Linear algebra tools are used to analyze the design, simplifying the process and shedding new insights. Nontrivial solutions of such system represent operating conditions that assure a productive biomass concentration. The design analysis helps to characterize the dilution rate and recirculation proportion avoiding wash-out problems. Therefore, the analysis given here paves the way towards the real implementation of continuous bioreactors in the industrial scale production. |
| Databáze: | OpenAIRE |
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