Recovery from Radiation Injury in the Hamster as Evaluated by the Split-Dose Technique
| Autor: | Leong Gf, E. J. Ainsworth, M. L. Albright, R. J. Holloway, S. J. Baum |
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| Rok vydání: | 1968 |
| Předmět: |
medicine.medical_specialty
Radiation Hematology medicine.diagnostic_test biology Biophysics Hamster Hematocrit biology.organism_classification Peripheral blood mononuclear cell Confidence interval Andrology Internal medicine Immunology medicine Radiology Nuclear Medicine and imaging Platelet Radiosensitivity Mesocricetus |
| Zdroj: | Radiation Research. 33:37 |
| ISSN: | 0033-7587 |
| DOI: | 10.2307/3572240 |
| Popis: | The split-dose technique was used to determine the pattern of recovery from radiation injury in the Syrian hamster (Mesocricetus auratus). Exposure of the animals to 1 Mvp X-rays resulted in a LD50/30 of 941 R (95% confidence interval: 917-967 R). Recovery, defined as a return to normal radiosensitivity after a sublethal exposure, was found to be non-exponential; in fact, a marked transient increase in radiosensitivity was observed during the second week. After exposure to 2/3 LD50/30, relatively little recovery was observed on the 3rd day after the conditioning exposure; 94% of the initial injury remained. Between the 3rd and 7th day the hamster recovered at a rapid rate; only 26% of the initial injury remained on day 7. These periods of recovery were followed by a regression of the animals to a more radiosensitive state; 76% of the initial injury was present on day 11. After this time, the animals returned toward more nearly normal radiosensitivity; 20% of the initial injury remained at day 20. These findings are a marked deviation from the exponential recovery pattern usually reported for other rodents. Hematological studies indicate that the extent of recovery, in terms of split-dose radiosensitivity, is not correlated with the number of circulating erythrocytes, thrombocytes, granulocytes, or mononuclear cells. (Author) |
| Databáze: | OpenAIRE |
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