Protective Effect of Cajanus cajan in Hepatotoxic Rats

Autor:	Iweala E. J. Emeka, O. Winifred, Evbakhavbokun
Rok vydání:	2019
Předmět:	Cajanus Traditional medicine biology Chemistry biology.organism_classification
Zdroj:	IOP Conference Series: Earth and Environmental Science. 331:012023
ISSN:	1755-1315 1755-1307
DOI:	10.1088/1755-1315/331/1/012023
Popis:	Hepatotoxicity results from overload of chemicals and drugs including N-Nitrosodiethylamine (NDEA), a nitrosamine found in smoke, meat and food products. This study examined the hepatoprotective potential of Cajanus cajan in male Wistar rats. Hepatotoxicity was induced by administration of NDEA at 200mg/kg while Cajanus cajan was administered at 200mg/kg, 400mg/kg and 800mg/kg for 28 days. Body weight, liver weight and markers of hepatotoxicity including Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Albumin (ALB) were evaluated. NDEA treated group showed a marginal increase in body weight and a significant (p < 0.05) increase in liver weight. The Cajanus cajan treated groups showed a significant (p < 0.05) increase and decrease respectively in body and liver weights. NDEA treated group significantly (PCajanus cajan significantly (PCajanus cajan ameliorates NDEA-induced hepatotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06b21168105ad93e55a396642d2e6dee https://doi.org/10.1088/1755-1315/331/1/012023 Zobrazit plný text záznamu