Time-dependant intercellular delamination of human stratum corneum

Autor:	Kenneth S. Wu, James Chien-Mo Li, Reinhold H. Dauskardt, K. P. Ananthapadmanabhan
Rok vydání:	2007
Předmět:	Materials science Mechanical Engineering Delamination Moisture diffusion chemistry.chemical_compound medicine.anatomical_structure chemistry Mechanics of Materials Tissue hydration Stratum corneum medicine General Materials Science Composite material Sodium dodecyl sulfate Intracellular
Zdroj:	Journal of Materials Science. 42:8986-8994
ISSN:	1573-4803 0022-2461
DOI:	10.1007/s10853-007-1831-3
Popis:	Time-dependent intercellular delamination behavior of human stratum corneum (SC) is explored. We demonstrate that SC is susceptible to such time-dependent subcritical delamination at loads below the critical delamination energy. Hydration of the SC together with chemical treatments using selected surfactants were shown to affect both critical and subcritical delamination behavior. Increased tissue hydration resulted in accelerated delamination growth rates consistent with behavior anticipated from critical delamination testing. Chemical treatments including 10% wt/wt sodium dodecyl sulfate (SDS) and chloroform-methanol (2:1 v:v) soaks that remove lipid were shown to suppress growth rates compared to untreated controls. Possible mechanisms for subcritical delamination involving extrinsic mechanisms of moisture-assisted reaction process at the intercellular delamination tip or intrinsic mechanisms involving kinetic relaxation processes in the SC are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06b0ca84904e0296f6e529106fd88637 https://doi.org/10.1007/s10853-007-1831-3 Zobrazit plný text záznamu Plný text ve formátu PDF