Development of a new staging system for patients with recurrent laryngeal squamous cell carcinoma
Autor: | D M B Peter Lacy, Jay F. Piccirillo |
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Rok vydání: | 1998 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty education.field_of_study business.industry Recurrent Laryngeal Squamous Cell Carcinoma Population Retrospective cohort study Laryngeal Neoplasm medicine.disease Head and neck squamous-cell carcinoma Epidermoid carcinoma Internal medicine medicine Stage (cooking) education business Survival rate |
Zdroj: | Cancer. 83:910-917 |
ISSN: | 1097-0142 0008-543X |
Popis: | BACKGROUND The management of recurrent head and neck squamous cell carcinoma can be challenging to both physician and patient. This is due at least in part to the lack of an accurate and clinically applicable staging system for these patients. The purposes of this study were to examine the survival patterns of patients presenting with recurrent laryngeal tumors, identify key factors affecting prognosis, and combine these factors to create a new staging system to predict survival. METHODS The methods included a retrospective chart review of 473 patients with laryngeal squamous cell carcinoma who received their initial treatment at Washington University between 1980 and 1992. From this population, 126 patients (27%) who developed recurrence were identified. RESULTS The overall 2-year survival rate was 40% (50 of 124 patients). Four variables affected survival: initial TNM stage, initial treatment, morphologic extent of recurrence, and treatment of recurrence. These variables were entered into a multivariate analysis to determine independent prognostic significance. Three variables were found to be statistically significant: TNM stage (chi-square = 4.6; P = 0.03), initial treatment (chi-square = 14.3; P = 0.0002), and extent of recurrence (chi-square = 19.4; P = 0.0001). The process of conjunctive consolidation was used to combine significant variables to create a new staging system for laryngeal recurrence. CONCLUSIONS This staging system provides accurate estimates of prognosis, involves no new technology to implement, can aid both the patient and physician in planning treatment, and can be used in observational studies to assess the relative effectiveness of competing therapies. Cancer 1998;83:910-917. © 1998 American Cancer Society. |
Databáze: | OpenAIRE |
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