| Autor: | J. Pialat, R. Duthel, Patrick Beauchesne, G. Clavreul, F. G. Barral, B. Laurent, T. Schmitt |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Chemotherapy medicine.diagnostic_test business.industry medicine.medical_treatment Astrocytoma medicine.disease Central nervous system disease Cerebrospinal fluid Neurology Oncology Biopsy medicine Methotrexate Meningeal Neoplasm Neurology (clinical) Pleocytosis business medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 37:161-167 |
| ISSN: | 0167-594X |
| DOI: | 10.1023/a:1005888319228 |
| Popis: | Primary leptomeningeal gliomatosis is rare, and the diffuse form (PLDG) is even more unusual. The following report is an example. A 17 year-old man developed a syndrome characterized by extensive basal and chronic spinal meningitis. Routine biological tests showed elevated levels of CSF proteins, and moderate mononuclear pleocytosis, with no direct evidence of neoplasia, leading to a diagnosis of chronic meningitis. A second meningeal biopsy, guided by MRI and performed in the left frontal region, led to the specific diagnosis of primary diffuse leptomeningeal gliomatosis. Treatment including ventricular and lumbar shunting, a course of cortico-spinal radiation, and three courses of an eight-drug systemic chemotherapy with intrathecal methotrexate lead to complete remission over 15 months. We believe that this is the first report of such a remission in the literature. |
| Databáze: | OpenAIRE |
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