ChemInform Abstract: Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines

Autor:	Tatiana Bogoslovova, P. D. Avramova, Rossen Buyukliev, Nicolai Danchev
Rok vydání:	2010
Předmět:	Sleeping time Chemistry Aryl Central nervous system General Medicine Pharmacology Acute toxicity In vitro chemistry.chemical_compound Hexobarbital medicine.anatomical_structure In vivo Morpholine medicine medicine.drug
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199915181
Popis:	The synthesis of nine original morpholine derivatives, i.e. 2-aryl-4-(3-arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and 1H-NMR, and some of them by 13C-NMR. Acute toxicity studies of the compounds were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time: locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was studied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria preparations.
Databáze:	OpenAIRE
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