| Autor: |
Raymond J. Geor, Tanja M. Hess, David S. Kronfeld, Raymond C. Boston, Pat Harris, K. H. Treiber |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Equine Veterinary Journal. 42:361-369 |
| ISSN: |
0425-1644 |
| Popis: |
Summary Reasons for performing study: Tools and criteria to evaluate and understand glucose metabolism are essential to optimise equine energy utilisation for exercise performance and reduced metabolic health risks. Objectives: To re-evaluate models of glucose kinetics in the horse at rest and during endurance type exercise using a single injection technique and compartmental modelling. Methods: Twelve exercise trained Arabian geldings received a bolus of 100 mmol/kg bwt (6,6- 2 H)glucose i.v. while at rest and while running at ~ 4m /s on a treadmill. Tracer and tracee glucose curves from 4-150 min after the bolus dose (while the subject maintained its resting or exercising state) were described by a 2 term exponential decay curve. Compartmental modelling was performed simultaneously for each horse's resting and exercise curves using an 'exercise effect' parameter for each compartmental exchange rate during exercise. Results: Exercise increased all rate constants and transport flows for glucose between compartments by 110-145% (P0.004). Total glucose transport through the system increased from 8.9 0.6 mmol/min/kg/bwt at rest to 25.0 1.1 mmol/min/kg bwt during exercise (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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