SOX-10 and S100 Negative Desmoplastic Melanoma: Apropos a Diagnostically Challenging Case
| Autor: | Daniel S Loo, Meera Mahalingam, Sarah Kooper-Johnson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Desmoplastic melanoma
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Cell Dermatology General Medicine Lentigo maligna medicine.disease Epidermal Inclusion Cyst Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Biopsy medicine Immunohistochemistry Cell tumor business |
| Zdroj: | The American Journal of Dermatopathology. 42:697-699 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000001626 |
| Popis: | An 83-year-old man presented with a tumor of the neck, clinically consistent with an epidermal inclusion cyst. Excisional biopsy revealed a deeply infiltrating spindled cell tumor. Immunohistochemical markers for S100, SOX-10, Melan-A, HMB-45, and NK1/C3 were negative. Based on the presence of an area of lentigo maligna and the histologic pattern of the spindle cell component, a diagnosis of desmoplastic melanoma was made despite the absence of immunophenotypic evidence for melanocytic differentiation. To the best of our knowledge, the complete lack of both S100 and SOX-10 makes this tumor an unprecedented case. To avoid ruling out the diagnosis of desmoplastic melanoma prematurely, physicians should be made aware of this possible immunohistochemical profile. |
| Databáze: | OpenAIRE |
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