Contrast-Enhanced Whole-Heart Coronary MRA using Gadofosveset
| Autor: | Armin Huber, Maximilian F. Reiser, Clemens C. Cyran, Kerstin Bauner, Maria Prompona, Konstantin Nikolaou |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Coronary magnetic resonance angiography medicine.diagnostic_test business.industry Image quality media_common.quotation_subject Gadofosveset medicine.disease Magnetic resonance angiography Surgery Coronary artery disease cardiovascular system Medicine Contrast (vision) Radiology Nuclear Medicine and imaging Prospective randomized study Nuclear medicine business Prospective cohort study media_common medicine.drug |
| Zdroj: | Academic Radiology. 17:862-870 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/j.acra.2010.02.009 |
| Popis: | Rationale and Objectives To compare contrast-enhanced coronary magnetic resonance angiography (MRA) at 3.0 T with the same technique performed at 1.5 T using the contrast agent gadofosveset. Materials and Methods In this prospective randomized study, 19 healthy male volunteers (mean age 28 years, mean weight 79.8 kg), after signing informed consents, underwent contrast-enhanced inversion recovery three-dimensional fast low angle shot (FLASH) MRA at 1.5 and at 3.0 T. Prospective electrocardiogram-triggering was combined with adaptive respiratory gating. For contrast-enhanced images, the intravascular contrast agent gadofosveset was used. Acquisition time, signal-to-noise ratio (SNR) of coronary blood, contrast-to-noise ratio (CNR) between coronaries and adjacent myocardium or epicardial fat and image quality were analyzed for statistical differences by using a two-tailed paired-sample t -test. The ratio calculations were based on measurements performed on the raw data and the image quality was blinded and independently evaluated by two experienced radiologists using a five-point scale. Results The mean values for the acquisition time were 14.58 ± 0.1 minutes at 1.5 T and 16.40 ± 0.2 minutes at 3.0 T. Overall SNR of all evaluated coronary segments proved higher at 3.0 T compared to 1.5 T (74.0 ± 42.1 at 3.0 T vs. 50.2 ± 20.2 at 1.5 T, P = .04). Overall CNR between coronaries and myocardium was significantly increased at 3.0 T in comparison to 1.5 T (40.1 ± 21.9 at 3.0 T vs. 24.4 ± 17.2 at 1.5 T, P = .01). Between the two methods, no significant difference in overall CNR between coronaries and epicardial fat was observed ( P = .08, NS). The 3.0 T MRA demonstrated superior overall image quality with respect to 1.5 T (2.28 ± 0.71 at 3.0 T vs. 1.92 ± 0.38 at 1.5T, P = .004). Conclusion The use of higher field strength, 3.0 T instead of 1.5 T, resulted in similar CNR between coronaries and epicardial fat, higher SNR values and CNR between blood and myocardium, as well as an improved overall image quality, when gadofosveset in combination with electrocardiogram and respiratory triggering for coronary MRA was used. |
| Databáze: | OpenAIRE |
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