Structural diversity of erythrocytes in patients with hereditary spherocytosis

Autor:	E. F. Mitsura, Maria N. Starodubtseva, A. N. Kondrachuk, N. I. Yegorenkov, Irina A. Chelnokova
Rok vydání:	2018
Předmět:	Genetics business.industry medicine Structural diversity In patient medicine.disease business Hereditary spherocytosis
Zdroj:	Health and Ecology Issues. :109-114
ISSN:	2708-6011 2220-0967
DOI:	10.51523/2708-6011.2018-15-2-22
Popis:	Objective: to study the shape of erythrocytes and structure of their surface layer including the membrane and cytoskeleton (actin-spectrin network) in child patients with hereditary spherocytosis. Material and methods. The methods of optic and atomic-force microscopy were used in the study. Results. A variety of erythrocyte shapes with such prevalent types as discocytes, spherocytes, and echinocytes were revealed in the blood of the patients. The surface of certain cells contained microvesicules. The spatial heterogeneity of the structure of mechanical property maps of the cell surface layer was detected. Conclusion. The diversity of erythrocyte features in patients with hereditary spherocytosis is present both at the level of the cell shapes and at the level of the structure of mechanical property maps of their surface layer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06793dcc8ce0b8441e4764d965374d34 https://doi.org/10.51523/2708-6011.2018-15-2-22 Zobrazit plný text záznamu