HLA-F: A New Kid Licensed for Peptide Presentation
| Autor: | Malcolm J. W. Sim, Peter D. Sun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Immunology Peptide Human leukocyte antigen Plasma protein binding Biology Major histocompatibility complex Molecular biology 03 medical and health sciences 030104 developmental biology Infectious Diseases chemistry Biochemistry biology.protein Immunology and Allergy Presentation (obstetrics) Receptor Groove (joinery) |
| Zdroj: | Immunity. 46:972-974 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2017.06.004 |
| Popis: | HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and can present a diverse array of peptides. LIR1, however, recognized HLA-F away from bound peptide, leaving open whether peptide-HLA-F-specific T and NK receptors exist. |
| Databáze: | OpenAIRE |
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