Propentofylline and postischemic brain edema: Relation to Na+-K+-ATPase activity

Autor:	V. Stefanovich, D. V. Mićić, B. B. Mršulja
Rok vydání:	1985
Předmět:	Sodium Potassium Ischemia chemistry.chemical_element Biological activity Pharmacology Xanthine medicine.disease Gerbil Propentofylline chemistry.chemical_compound chemistry Anesthesia Drug Discovery medicine Na+/K+-ATPase
Zdroj:	Drug Development Research. 6:339-344
ISSN:	1098-2299 0272-4391
Popis:	Following the bilateral occlusion of common carotid arteries in gerbil, an increase in water content and sodium/potassium ratio as well as the inhibition of Na+-K+-ATPase was found. The xanthine derivative propentofylline (HWA 285) [3-methyl-1-(5-oxohexyl)-7-propylxanthine] given either before or after cerebral ischemia attenuated the development or postischemic brain swelling and the increase in sodium/potassium ratio and prevented the postischemic reduction of Na+-K+-ATPase activity. It is concluded that the action of propentofylline on brain edema during ischemia is mediated aside from other possible mechanism(s), by the influence of the drug on Na+-K+-ATPase activity.
Databáze:	OpenAIRE
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