Capillary Basement Membrane Changes in Adolescents With Type 1 Diabetes

Autor:	Robert L. Jackson, Richard A. Guthrie, James A. Esterly, Helen B. Waiches, John E. Hewett
Rok vydání:	1982
Předmět:	Basement membrane Type 1 diabetes medicine.medical_specialty Basement Membrane Thickness business.industry General Medicine medicine.disease medicine.anatomical_structure Endocrinology Metabolic control analysis Internal medicine medicine business Normal range
Zdroj:	JAMA: The Journal of the American Medical Association. 248:2143
ISSN:	0098-7484 2143-2147
DOI:	10.1001/jama.1982.03330170047026
Popis:	Measurements were made of muscle capillary basement membrane thickness (CBMT) in 95 normal boys and girls and 167 postpubescent insulin-dependent diabetics. Of 110 diabetics in whom "higher" degrees of metabolic control were maintained, only two had increased CBMT values. Of 57 diabetics in whom "lower" degrees of metabolic control were maintained, 26 had increased CBMT values. Two or more muscle biopsies were done in each of 65 diabetic subjects: Mean CBMT values of 24 subjects with "higher" degrees of metabolic control for two to nine years remained within the normal range; values of 23 subjects with "lower" degrees of metabolic control for only one to three years increased from 858±142 A to 1,155 ± 227 A; values of 13 subjects who had been in "lower" degrees of control decreased from 1,255 ±232 A to 869 ±135 A after maintaining "improved" metabolic control for about a year. In postpubescent diabetics, the CBMT is labile and progresses or regresses depending on the degree of metabolic control. ( JAMA 1982;248:2143-2147)
Databáze:	OpenAIRE
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