A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial

Autor:	N.P. Sanchez, A. Bucko, Michael Jarratt, J.-C. Dhuin, Rod Kunynetz, Nabil Kerrouche, S. Kempers, Joseph F. Fowler, Yves Poulin
Rok vydání:	2011
Předmět:	medicine.medical_specialty business.industry Adapalene/benzoyl peroxide Dermatology Benzoyl peroxide Relapse prevention medicine.disease law.invention Lesion Maintenance therapy Randomized controlled trial Adapalene law Internal medicine medicine medicine.symptom business Acne medicine.drug
Zdroj:	British Journal of Dermatology. 164:1376-1382
ISSN:	0007-0963
Popis:	Summary Background Acne vulgaris is a chronic and frequently recurring disease. A fixed-dose adapalene-benzoyl peroxide (adapalene-BPO) gel is an efficacious and safe acne treatment. Objectives To assess the long-term effect of adapalene-BPO on relapse prevention among patients with severe acne after successful initial treatments. Methods This is a multicentre, double-blind, randomized and controlled study. In total, 243 subjects who had severe acne vulgaris and at least 50% global improvement after a previous 12-week treatment were randomized into the present study to receive adapalene-BPO gel or its vehicle once daily for 24 weeks. Results At week 24, compared with vehicle, adapalene-BPO resulted in significantly higher lesion maintenance success rate (defined as having at least 50% improvement in lesion counts achieved in initial treatment) for all types of lesions (total lesions: 78·9% vs. 45·8%; inflammatory lesions: 78·0% vs. 48·3%; noninflammatory lesions: 78·0% vs. 43·3%; all P
Databáze:	OpenAIRE
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