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Department of Chemistry, Government Post-Graduate College, Chum-831 001 (Rajasthan) Manuscript received 24 March 1980, accepted 7 August 1980 The reaction of 4-amino-5-mercapto-3-substituted-s-triazoles(I) with ehloranil and α-haloketones furnished 3, 10 -disubstituted-6, 13-dichloro, bis(s-triazolo[3,4 : 2'3'] [1,3,41 thiadiazino[5',6'-b : 5',6'-e]) cyclohexa-1,4-diene(II) and 7H-3,6-disubstituted-s-triazolo[3,4-b][1,3,4] thiadiazoles(III) respectively. Similarly reaction of I with aromatic carboxylic acids and oxalic acid in presence of phosphorous oxychioride gave s-triazolo [3,4-b][1,3,4]thiadiazoles(IV) and 6,6'-bis(3,6-diphenyl-s-triazolo 13,4-b][1,3,41 thiadiazoles(V) respectively, whereas with α-chloroacetic acid afforded 7H-3-phenyl-s- triazolo thiadiazin 6(5H)-one(VI). Some of the compounds were screened for their antitumor activity. |
