Radical (Phenylsulfonyl)difluoromethylation of Isocyanides with PhSO2CF2H under Transition-Metal-Free Conditions

Autor:	Pan Xiao, Junkai Guo, Chuanfa Ni, Jian Rong, Jinbo Hu, Dingben Chen, Xinjin Li
Rok vydání:	2016
Předmět:	Deprotonation Transition metal 010405 organic chemistry Chemistry Group (periodic table) Organic Chemistry Organic chemistry Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences
Zdroj:	Organic Letters. 18:5912-5915
ISSN:	1523-7052 1523-7060
Popis:	An atom-economical method for radical (phenylsulfonyl)difluoromethylation of isocyanides with PhSO2CF2H under transition-metal-free conditions has been developed. A PhSO2CF2 radical is generated through the oxidation of PhSO2CF2– after the deprotonation of PhSO2CF2H in one pot. The reaction exhibits excellent functional-group tolerance and the resulting products can be further modified with the removal of a PhSO2 group to give other CF2-containing compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::065380daca0e206fd53b974516c7595a https://doi.org/10.1021/acs.orglett.6b03013 Zobrazit plný text záznamu