Palladium-catalyzed cascade one-pot synthesis of 5-arylmethylisoxazolidines from N-homoallylhydroxylamines with aryl bromides

Autor:	Dahong Jiang, Jinsong Peng, Yuanwei Chen
Rok vydání:	2008
Předmět:	Chemistry Aryl education Organic Chemistry One-pot synthesis Intermolecular force chemistry.chemical_element Bond formation Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Cascade Intramolecular force Drug Discovery Organic chemistry Palladium
Zdroj:	Tetrahedron. 64:1641-1647
ISSN:	0040-4020
DOI:	10.1016/j.tet.2007.12.014
Popis:	A novel method for the synthesis of 5-arylmethylisoxazolidines via palladium-catalyzed reactions of aryl bromides with N -homoallylhydroxylamines is described. This reaction effects intramolecular C–O bond formation with concomitant intermolecular formation of a C–C bond in moderate to good yields. Moderate to excellent diastereoselectivities are observed for the formation of the isoxazolidines. The catalytic system has a tolerance to a wide variety of functional groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::064fc81dccc51774dea4e9855b754825 https://doi.org/10.1016/j.tet.2007.12.014 Zobrazit plný text záznamu Full Text from ScienceDirect