Antibiofilm activity of host defence peptides: complexity provides opportunities

Autor:	Evan F. Haney, Robert E. W. Hancock, Morgan A. Alford
Rok vydání:	2021
Předmět:	Antifungal 0303 health sciences Innate immune system General Immunology and Microbiology 030306 microbiology medicine.drug_class Antibiotics Antimicrobial peptides Host defence Computational biology Biology Antimicrobial Microbiology 03 medical and health sciences Infectious Diseases medicine
Zdroj:	Nature Reviews Microbiology. 19:786-797
ISSN:	1740-1534 1740-1526
DOI:	10.1038/s41579-021-00585-w
Popis:	Host defence peptides (HDPs) are integral components of innate immunity across all living organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells (referred to as antimicrobial peptides), and exhibit antibiofilm (referred to as antibiofilm peptides), antiviral, antifungal and host-directed immunomodulatory activities. In this Review, we discuss how the complex functional attributes of HDPs provide many opportunities for the development of antimicrobial therapeutics, focusing particularly on their emerging antibiofilm properties. The mechanisms of action of antibiofilm peptides are compared and contrasted with those of antimicrobial peptides. Furthermore, obstacles for the practical translation of candidate peptides into therapeutics and the potential solutions are discussed. Critically, HDPs have the value-added assets of complex functional attributes, particularly antibiofilm and anti-inflammatory activities and their synergy with conventional antibiotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::064b1e4b6787dd07b3dc9e2b3dd264ce https://doi.org/10.1038/s41579-021-00585-w Zobrazit plný text záznamu Full text from SpringerLink