Three-Domain Antibodies against the Tumor Necrosis Factor: Investigation of Their Biological Activity In Vitro
| Autor: | Ekaterina A. Vasilenko, Irina V. Astrakhantseva, Sergei A. Nedospasov, Vladislav V. Mokhonov, E. N. Gorshkova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Necrosis biology 010405 organic chemistry Chemistry Organic Chemistry Biological activity 01 natural sciences Biochemistry In vitro 0104 chemical sciences Cell biology Human tumor 03 medical and health sciences 030104 developmental biology medicine biology.protein Macrophage Bioorganic chemistry Tumor necrosis factor alpha medicine.symptom Antibody |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 46:299-305 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | The aim of this work was to evaluate novel three-domain antibodies consisting of two domains specific for human tumor necrosis factor (hTNF), and of the third domain responsible for binding to myeloid cells. The additional hTNF-binding domain should serve to increase the biological activity of new antibodies. Capacity of these proteins to bind hTNF on the macrophage surface and to neutralize its biological activity in vitro was assessed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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