Sericin from Antheraea proylei J. cocoons as Genotoxic inducing cell death through activation of p38 in PC3 cells

Autor:	Potsangbam Jolly Devi, Asem Robinson Singh, Lisam Shanjukumar Singh, L. Rupachandra Singh, S. Kunjeshwori Devi
Rok vydání:	2022
Předmět:	Bioengineering Applied Microbiology and Biotechnology Biotechnology
Zdroj:	Research Journal of Biotechnology. 17:13-19
ISSN:	2278-4535 0973-6263
DOI:	10.25303/1709rjbt13019
Popis:	Sericin is a byproduct of silk fibre industries with potential applications in therapeutics and cosmetic industries. Sericin protein differs in amino acid composition pertaining to the habitat and species of the silkworm. Though antiproliferative activity of sericin from B. mori is documented, sericin from A. proylei remains largely unexplored on various cell lines. The study envisages use of sericin protein as an anticancer agent in prostate cancer by using PC3 cells as a model. The study reports a caspase-3 and PARP independent cell death mechanism in PC3 cells treated with sericin and its ability to induce apoptosis through activation of p38 and arrests of cell cycle at G0/G1 phase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06401ad4f45cef49240e4c56d5221901 https://doi.org/10.25303/1709rjbt13019 Zobrazit plný text záznamu