Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating

Autor:	Honggu Choi, Rishyashring R Iyer, Carlos A Renteria, Stephen A Boppart
Rok vydání:	2023
Předmět:	Radiological and Ultrasound Technology Radiology Nuclear Medicine and imaging
Zdroj:	Physics in Medicine & Biology. 68:065005
ISSN:	1361-6560 0031-9155
DOI:	10.1088/1361-6560/acbf9c
Popis:	Non-ergodicity of neuronal dynamics from rapid ion channel gating through the membrane induces membrane displacement statistics that deviate from Brownian motion. The membrane dynamics from ion channel gating were imaged by phase-sensitive optical coherence microscopy. The distribution of optical displacements of the neuronal membrane showed a Lévy-like distribution and the memory effect of the membrane dynamics by the ionic gating was estimated. The alternation of the correlation time was observed when neurons were exposed to channel-blocking molecules. Non-invasive optophysiology by detecting the anomalous diffusion characteristics of dynamic images is demonstrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0633d21e2e7b9e2d2137fbdbf37fe594 https://doi.org/10.1088/1361-6560/acbf9c Zobrazit plný text záznamu