SYNTHESIS AND EVALUATION OF SOME NEW SUBSTITUTED PIPERAZINYL-ARYL AMIDE, ACETAMIDE, AND SULFONAMIDE DERIVATIVES OF ROSUVASTATIN INTERMEDIATE AND THEIR ANTI-MICROBIAL ACTIVITY

Autor:	Donka Suresh Babu, Doddaga Srinivasulu, Valaparla Bala Yesu, V.V.P.C. Narayana, Murali Vatturu, Sajitha Kethineni, Meriga Balaji
Rok vydání:	2023
Předmět:	General Energy General Chemical Engineering General Chemistry General Pharmacology Toxicology and Pharmaceutics Biochemistry
Zdroj:	RASAYAN Journal of Chemistry. 16:527-535
ISSN:	0976-0083 0974-1496
Popis:	In pursuit of a biodynamically potent molecule, we have attempted to synthesize derivatives of piperazine by incorporating them into the Rosuvastatin intermediate. The reason behind this is that heterocyclic compounds with nitrogen atoms in their ring structure, such as pyrimidine, have great potential as drug design scaffolds. By doping piperazine into the Rosuvastatin intermediate, a series of new derivatives made up of aryl-amides, acetamides, and sulfonamides were produced. These derivatives were then assessed for their antimicrobial activity, with a few showing promising results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0630e0c393d0e74396daf0580d980acb https://doi.org/10.31788/rjc.2023.1618008 Zobrazit plný text záznamu Plný text ve formátu PDF