Evaluation of indirect damage and damage saturation effects in dose-response curves of hypofractionated radiotherapy of early-stage NSCLC and brain metastases
| Autor: | Antonio Gómez-Caamaño, M. Pombar, Sara Neira, Araceli Gago-Arias, Juan Pardo-Montero |
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| Rok vydání: | 2020 |
| Předmět: |
Hypofractionated Radiotherapy
Oncology medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease Tumor control 030218 nuclear medicine & medical imaging Dose prescription Radiation therapy 03 medical and health sciences Formalism (philosophy of mathematics) Dose–response relationship 0302 clinical medicine Lq model 030220 oncology & carcinogenesis Internal medicine Medicine business Cell damage |
| DOI: | 10.1101/2020.08.26.20182287 |
| Popis: | BackgroundIn this work we aim to investigate the possible contribution of indirect damage and damage saturation to tumor control probabilities (TCP) obtained with SBRT/SRS treatments for early-stage NSCLC and brain metastases.MethodsWe have constructed a dataset of early-stage NSCLC and brain metastases response to different fractionations. Dose-response curves were fitted to models based on the linear-quadratic (LQ), the linear-quadratic-linear (LQL), and phenomenological modifications of the LQ model to account for indirect cell damage. We used the Akaike-Information-Criterion formalism to compare performance, and studied the stability of the results with changes in fitting parameters and perturbations on dose/TCP values.ResultsIn NSCLC, a modified LQ model with a beta-term increasing with dose yields better results than the LQ model. This rank remains consistent when different fitting parameters are changed, and only the inclusion of very fast accelerated proliferation can eliminate the superiority of the modified LQ. In brain, the LQL model yields the best-fits, and the ranking is not affected by variations of fitting parameters or dose/TCP perturbations.ConclusionsA modification of the LQ model with a beta-term increasing with dose provides better fits to NSCLC dose-response curves. For brain metastases, the LQL provides the best fit. This may be interpreted as a net contribution of indirect damage in NSCLC, and damage saturation in brain metastases. The results for NSCLC are borderline significant, while those for brain are clearly significant. Our results can assist on the design of optimal radiotherapy for NSCLC and brain metastases, aiming at avoiding over/under-treatment. Dose prescription to such tumors may be reevaluated according to the reported evidence. |
| Databáze: | OpenAIRE |
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