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Background The protective effect of the inactivated vaccine against the omicron variant of COVID-19 is unclear. The purpose of this study was to investigate the protective effect of different vaccination status on omicron infection. Methods In this retrospective study, we analyzed patients over 14 years old, and were diagnosed with immune breakthrough Omicron-variant infection between December 2021 and February 2022 in Tianjin, China, as well as data from several previous study infected by other types of SARS-CoV-2. The data were subdivided into three groups: patients with fully, partially and unvaccine. Differences of clinical and imaging characteristics were compared based on the different vaccination status using Pearson Chi-square test, Fisher's accuracy test and non-parametric test. All of the data were also compared with other types of SARS-CoV-2. Logistic regression and mediation effect analysis were used to assess the association between vaccination status and pneumonia progression during hospitalization. Results Among the 314 cases of immune breakthrough Omicron-variant infected patients, 21(7%) patients were unvaccinated, 134 (43%) were partially vaccinated, and 159 (50%) were full vaccinated. Among fully vaccinated patients, the proportion of patients with positive CT findings (32%) and CT score 2 (6%) was significantly lower than that of partially vaccinated (46%, 14%) and unvaccinated patients (67%, 19%) (P |
