Thymectomy for NonthymomatousMyasthenia Gravis
| Autor: | Joshua R. Sonett, Alfred Jaretzki |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Response to therapy business.industry General Neuroscience medicine.medical_treatment Treatment outcome MEDLINE medicine.disease General Biochemistry Genetics and Molecular Biology Myasthenia gravis Surgery Thymectomy Remission induction History and Philosophy of Science medicine Prospective cohort study business Intensive care medicine |
| Zdroj: | Annals of the New York Academy of Sciences. 1132:315-328 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1196/annals.1405.004 |
| Popis: | There continues to be debate concerning which thymectomy technique is the procedure of choice in the treatment of nonthymomatous myasthenia gravis (MG). The debate persists primarily because of the lack of controlled prospective studies but also because of the varying presentations and clinical courses of MG patients. Analysis has been complicated by the absence, until very recently, of accepted objective definitions of severity of the illness and response to therapy as well as variable patient selection, timing of surgery, type of surgery, and methods of analysis of results. Without resolution of these issues by properly designed prospective studies, there can be no unequivocally valid comparison of the various thymectomy techniques. In this review, attempts have been made to clarify some of the controversial issues concerning the selection of a thymectomy technique in the treatment of nonthymomatous MG and to make limited recommendations based on the best available evidence. |
| Databáze: | OpenAIRE |
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