Lithium iodide-promoted aldol condensation reactions

Autor:	M. Anthony McKervey, Pongsak Vibuljan, Roger G. Kelleher
Rok vydání:	1980
Předmět:	chemistry.chemical_classification Trimethylsilyl Ether Medicinal chemistry chemistry.chemical_compound Lithium iodide chemistry Reagent Molecular Medicine Organic chemistry Aldol condensation Enone Tetrahydrofuran Alkyl
Zdroj:	Journal of the Chemical Society, Chemical Communications. :486
ISSN:	0022-4936
DOI:	10.1039/c39800000486
Popis:	Anhydrous lithium iodide in ether, tetrahydrofuran, or benzene is an effective reagent for the formation of αβ-unsaturated ketones by condensation of alkyl ketones with enolisable and non-enolisable aldehydes; in the presence of trimethylchlorosilane–triethylamine enone formation is suppressed and high yields of 1,3-hydroxy-ketones are obtained as their trimethylsilyl ether derivatives.
Databáze:	OpenAIRE
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