Irx5 and transient outward K+ currents contribute to transmural contractile heterogeneities in the mouse ventricle

Autor:	Kyoung-Han Kim, Yena Oh, Jie Liu, Saif Dababneh, Ying Xia, Ri Youn Kim, Dae-Kyum Kim, Kiwon Ban, Mansoor Husain, Chi-Chung Hui, Peter H. Backx
Rok vydání:	2022
Předmět:	Physiology Physiology (medical) cardiovascular system cardiovascular diseases Cardiology and Cardiovascular Medicine
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 322:H725-H741
ISSN:	1522-1539 0363-6135
Popis:	Irx5 is a vital transcription factor that establishes the transmural heterogeneity of ventricular myocyte contractility, thereby ensuring proper contractile function in the healthy heart. Regional differences in excitation-contraction coupling in the ventricular myocardium are primarily mediated through the inverse relationship between Irx5 and the fast transient outward K+ current ( Ito,f) across the ventricular wall.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0616e9c9d8f55b889e457fd4d112f54d https://doi.org/10.1152/ajpheart.00572.2021 Zobrazit plný text záznamu