ChemInform Abstract: Synthesis and Antinociceptive Activity of Some 3-Substituted Benzothiazolone Derivatives

Autor:	Aysel Ulucay, M. Fethi Şahin, Deniz S. Dogruer, Bilge Çakir, Askin Isimer
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Morpholine General Medicine Spectral data Medicinal chemistry
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200013097
Popis:	Thirteen 3-substituted benzothiazolone derivatives have been synthesized. Their chemical structures have been elucidated by IR and NMR spectral data and by elemental analyses. Among these compounds, 1-?3-[2(3H)-benzothiazolon-3-yl[propanoyl]morpholine (5b); 1-?3-[2(3H)-benzothiazolon-3-yl[propanoyl]-4-benzylpiperidine++ + (5c); 1-?3-[2(3H)-benzothiazolon-3-yl[-propanoyl]-4-phenylpiperazine (5d); 3-[3-(4-benzylpiperidine-1-yl)propyl]-2(3H)-benzothiazolone (5k); 3-[3-(4-benzylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5I); 3-[3-(4-phenylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5m) have been found to be significantly more active than the others.
Databáze:	OpenAIRE
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