iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study
| Autor: | Naoshi Sugimoto, Junya Kanda, Sou Nakamura, Toshiyuki Kitano, Masakatsu Hishizawa, Tadakazu Kondo, Shin Shimizu, Akiko Shigemasa, Hideyo Hirai, Yasuyuki Arai, Manabu Minami, Harue Tada, Dai Momose, Ki-Ryang Koh, Masayuki Nogawa, Naohide Watanabe, Shinichiro Okamoto, Makoto Handa, Akira Sawaguchi, Nobuki Matsuyama, Mitsunobu Tanaka, Tomoya Hayashi, Akihiro Fuchizaki, Yoshihiko Tani, Akifumi Takaori-Kondo, Koji Eto |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Blood. 140:2398-2402 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.2022017296 |
| Popis: | Refractoriness to platelet transfusion is a major problem in a small group of patients, and large-scale manufacturing of clinical grade functional platelets ex vivo has remained an elusive goal. Sugimoto et al report on the results of the first clinical trial of an autologous transfusion of induced pluripotent stem cell (iPSC)-derived platelets in a patient who had severe aplastic anemia but no compatible platelet donor. Using methodology described in a complementary article in Blood Advances, the results provide proof-of-principle and illustrate the challenges to be faced in taking this approach further. |
| Databáze: | OpenAIRE |
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