Selective competitive inhibition of accumulation of rosette-forming cells during the immune response

Autor:	A. Ya. Kul'berg, Golovanova Ta, S. A. Simonyan, B. L. Yurin, Khorobrykh Vv
Rok vydání:	1976
Předmět:	B-1 cell CD40 Immune system biology Antigen Polyclonal B cell response Antigen presentation biology.protein General Medicine Acquired immune system Antigen-presenting cell Molecular biology General Biochemistry Genetics and Molecular Biology
Zdroj:	Bulletin of Experimental Biology and Medicine. 81:888-891
ISSN:	1573-8221 0007-4888
Popis:	Repeated injection of rabbit immunoglobulins into mice before immunization with sheep's red cells inhibits the process of accumulation of rosette-forming cells but does not affect proliferation of antibody-forming cells or hemagglutinin production. Under these conditions the number of rosette-forming cells is reduced on account of the B cells, whose antigen-binding receptors may be blocked by means of antibodies against aggregated mouse immunoglobulins and polyA:polyU complex. Repeated injection of the competing antigen was shown to stimulate the formation of immunological memory for the second antigen. The question of the origin of the immune rosette-forming B cells and their effect on the formation of immunological memory is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0614daf86a5a481db51935cd97bfce7d https://doi.org/10.1007/bf00803013 Zobrazit plný text záznamu Full text from SpringerLink