Vitamin D and primary hypothyroidism: Is there an association?

Autor:	Pooja Prakash Prabhu, Subramanian Kannan, Rekha Pradeep, Jyothi Idiculla, Kranti Khadilkar
Rok vydání:	2018
Předmět:	0301 basic medicine endocrine system medicine.medical_specialty 030109 nutrition & dietetics endocrine system diseases business.industry Cross-sectional study Primary hypothyroidism 030209 endocrinology & metabolism medicine.disease Age and sex Gastroenterology vitamin D deficiency 03 medical and health sciences Single centre 0302 clinical medicine Internal medicine medicine Vitamin D and neurology General Earth and Planetary Sciences Euthyroid In patient business hormones hormone substitutes and hormone antagonists General Environmental Science
Zdroj:	Thyroid Research and Practice. 15:34
ISSN:	0973-0354
DOI:	10.4103/trp.trp_49_17
Popis:	Background: Association studies between the vitamin D deficiency (VDD) and hypothyroidism have given mixed results. Because of this controvery and relatively common prevalence of these two conditions, we conducted a case-control study investigating the prevalence of VDD in patients with hypothyroidism (both TPO-Ab positive and negative) and compared it with euthyroid controls. Methodology: This is a single centre cross sectional study. Adults (aged 18 years or more) of both the sexes diagnosed with primary hypothyroidism (TSH >5.1 mIU/L) were included (n = 115) along with age and sex matched euthyroid (TSH Results: Patients in the hypothyroid group [38 (males) and 77 (females)] had a mean (SD) age 46 (15) years, while the euthyroid control group [24 (males) and 96 (females) had a mean (SD) age of 45 (17) years. In the hypothyroid group, 96% (110/115) had VDD as compared to 90% (108/120) in the control group with a significantly lower mean Vit D level was observed in the hypothyroid group as compared to the euthyroid group (12+8.6 vs 17.49+11.89 ng/ml; P Conclusion: The vitamin D levels in patients with hypothyroidism were significantly lower compared to euthyroid controls.TPO-Ab positive patients had lower levels of vitamin D in comparison with negative
Databáze:	OpenAIRE
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