PLGA 50:50 nanoparticles of paclitaxel: Development, in vitro anti-tumor activity in BT-549 cells and in vivo evaluation

Autor:	Aravind Kumar Gurram, Naseer Maliyakkal, Gopal V. Shavi, Praful B. Deshpande, Udupa Nayanabhirama, Karthik Arumugam, Sreenivasa R Meka, Ranjith Kumar Averineni
Rok vydání:	2012
Předmět:	Materials science Pharmacology In vitro PLGA chemistry.chemical_compound chemistry Pharmacokinetics Paclitaxel Mechanics of Materials In vivo Drug delivery Pharmaceutics General Materials Science Solubility
Zdroj:	Bulletin of Materials Science. 35:319-326
ISSN:	0973-7669 0250-4707
DOI:	10.1007/s12034-012-0313-7
Popis:	Clinical administration of paclitaxel is hindered due to its poor solubility, which necessitates the formulation of novel drug delivery systems to deliver such extreme hydrophobic drug. To formulate nanoparticles which makes suitable to deliver hydrophobic drugs effectively (intravenous) with desired pharmacokinetic profile for breast cancer treatment; in this context in vitro cytotoxic activity was evaluated using BT-549 cell line. PLGA nanoparticles were prepared by emulsion solvent evaporation technique and evaluated for physicochemical parameters, in vitro anti-tumor activity and in vivo pharmacokinetic studies in rats. Particle size obtained in optimized formulation was
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::06075ddeb5c9bedc56ea33ec9dcb890b https://doi.org/10.1007/s12034-012-0313-7 Zobrazit plný text záznamu Plný text ve formátu PDF